In the STEP 5 trial published in Nature Medicine, semaglutide produced an average weight loss of about 15% over two years, and many patients do exceptionally well on it
It also shows that tirzepatide affects the receptors differently, internalizing GIP receptors fully but only partially affecting GLP-1 receptors
As a GLP-1, semaglutide drugs like Ozempic and Wegovy work by : Slowing down how quickly food leaves your stomach Regulating your appetite by sending signals of satiety (fullness) to your brain Encouraging your pancreas to release more insulin after you eat Reducing the amount of glucose produced by your liver Together, these effects help you feel full longer, reduce cravings, and keep your blood sugar levels in check
Furthermore, these agents lead to a delay in gastric emptying [5], resulting in satiety and consequently reducing food intake
Manish Sahni, MD at Centra Internal Medicine Does tirzepatide only reduce weight, or does it also improve metabolic health (blood sugar, cholesterol, etc.)
