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Senescent cells within the tumor microenvironment secrete a cascade of proinflammatory factors that promote tumorigenesis by inducing epigenetic instability, increasing cell proliferation, and stimulating angiogenesis

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The reduced viable Salmonella counts in liver and spleen of the cystine-fed rats in our study may have resulted from decreased Salmonella translocation from the gut or from enhanced killing of translocated pathogens by the innate immune system, e.g

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Considering that PSC activation is a key factor in pancreatic fibrosis, we speculated that excess ROS production induced by high glucose may induce PSC activation in vivo