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In terms of mechanisms, following release, GH binds to its receptor leading to the recruitment and phosphorylation of Janus kinase 2 (JAK2) and its most recognized downstream target, signal transducer and activator of transcription 5 (STAT5) (Jrgensen et al., 2006)

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Tirzepatide, the GLP-1 and GIP-receptor dual agonist is described, and weight loss is compared to alternative anti-obesity medications

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Int J Radiat Oncol Biol Phys 74(2):482-9, 2009