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For adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) CALQUENCE Dosage FIXED-DURATION TREATMENT FOR PREVIOUSLY UNTREATED CLL/SLL Treatment cycles (each cycle is 28 days, or 4 weeks) CONTINUOUS TREATMENT FOR PREVIOUSLY UNTREATED AND PREVIOUSLY TREATED CLL/SLL *Take each tablet by mouth

doi: 10.1210/jc.2010-1587 77 Johns Hopkins University

Establishing that semaglutide carries a higher risk and that other GLP-1s dont share that risk to the same degree can strengthen your case

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They: Slow gastric emptying, which can help you feel fuller longer Increase the release of insulin when sugar is present, which can help ward off spikes and crashes in blood sugar levels Suppress glucagon secretion, which in turn reduces liver glucose output Stimulate glucose uptake into cells and increase glucose uptake and storage in muscles so you have energy at the ready Increase proliferation of the beta cells in the pancreas that make insulin, which boosts the availability of blood-sugar-modulating insulin Decrease hunger through multiple pathways in the brain, including a quieting of food noise that can reduce the drive to binge eat or seek emotional comfort in food Taken together, these actions often add up to rapid and significant weight loss