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Tesamorelin activates the GHRH pathway using cAMP as a second messenger

10.1016/j.fct.2013.08.049 71 KaplowitzN.JiC

Since an IGF-1R construct, in which the tyrosine at position 1136 was replaced by a phenylalanine, also led to a strong inhibition of phosphorylated Akt in transfected cells, it was suggested that this mechanism may be responsible for the apoptotic effect of PPP (Vasilcanu et al, 2004)