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Low blood sugar (hypoglycemia) risk increases when used with other glucoselowering drugs (especially insulin or sulfonylureas)

Newson J, Motwani MP, Kendall AC et al (2017) Inflammatory resolution triggers a prolonged phase of immune suppression through COX-1/mPGES-1-derived prostaglandin E(2)

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Additionally, metformin is recommended either as a standalone treatment or alongside other medications, primarily for managing metabolic features of PCOS