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Gabapentin, on the other hand, does not directly act as GABA but influences calcium channels in nerve cells to reduce excitability
The medication works by slowing gastric emptying and regulating hunger signals in the brain
It emulates the function of incretin hormone glucagon-like peptide-1 (GLP-1) found in the human body
The investigation has been approved by the Ethical Committee of the Faculty of Pharmacy, Cairo University, approval number (PT3521), and the Ethical Committee for Animal Experimentation at the Faculty of Pharmacy, MSA University, approval number (PH16/REC16/2023MSc), based on the ethics guideline for the care and use of animals, and according to the 2014 Egyptian Constitutions article 45, the World Organization for Animal Health (WOAH), and the Guide for the Care and Use of Laboratory Animals, 8th Edition 2011
The biological mechanisms underlying these associations remain uncertain, as available human data are limited and largely speculative
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