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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

[7] To minimize such effects, clinics now administer NAD+ infusions slowly (over several hours) or use divided subcutaneous doses

Its gastric stability makes it particularly suited for GI research, though human clinical evidence is currently absent

Importantly, these effects occurred at rates similar to placebo groups, suggesting that many cases represented background occurrence rather than treatment-specific effects

If your body has trouble absorbing B12 from food or oral supplements, injections can be a game-changer