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Severe Gastrointestinal Disease (e.g., gastroparesis): Because semaglutide slows gastric emptying, it may worsen symptoms in individuals with severe stomach or bowel motility issues
In epidemiological studies, we observed that kidney function is the main modifiable factor consistently regulating fasting serum TMAO levels, and our preclinical studies align with the suggestion that elevated circulating TMAO adversely affects kidney function, by increasing kidney fibrotic injury
Targeted delivery of p-coumaric acid encapsulated mannosylated liposomes to the synovial macrophages inhibits osteoclast formation and bone resorption in the rheumatoid arthritis animal model
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2018;17:e12459
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