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Other analogues with marked efficacy in preclinical studies, including non-peptide AMYR agonists are under development. Promising Candidates in Development At this point, it is hard to say which, if any, of these candidates will turn out to deliver important clinical advantages

PLoS One 9, e101740, 10.1371/journal.pone.0101740 (2014)

The persistence of effects without continuous receptor occupation suggests DSIP may trigger gene expression changes rather than requiring constant pharmacological presence

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