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Saneto, RP, Cohen, BH, Copeland, WC, Naviaux, RK 2013, Alpers-Huttenlocher Syndrome, Pediatric Neurology , vol

The generation of mutants for selected genes based on transcriptomic data, using advanced techniques such as CRISPR/Cas9, will further open new horizons for developing resistance to viruses or other multifactorial stresses

doi: 10.1016/S0378-4347(01)00110-4 176 VighiGMarcucciFSensiLdi CaraGFratiF

Instead, they deliver nutritional building blocksincluding L-tyrosine (a melanin precursor), copper (a cofactor for tyrosinase enzyme activity), zinc, vitamin B12, and sometimes plant-based antioxidants like lutein or beta-carotene

rather, use of such a strategy would subject more patients to overtreatment without much added benefit, leading to increasing healthcare costs as patients are often treated for acute APAP hepatotoxicity in medical intensive care units to ensure close monitoring of vital signs and the ability for frequent neurologic assessments