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In cultured adipocytes and several mouse models, 5-Amino-1MQ reduced the NNMT activity marker 1-methylnicotinamide and was associated with changes in adiposity, glucose handling, liver histology and aged-muscle performance

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Although, there are no human data describing the effect of GIP activity on memory and other cognitive functions, several animal studies have shown that activation of the GIP receptor has a profound effect on neuronal plasticity (108)