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It is a particular factor during the early phases of treatment and mentioned as something to monitor in cases of severe anaemia in NICE guidelines

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First, it did not compare metformin with a well-established pharmacological control, which limits direct benchmarking against existing therapeutic options

Importantly, several studies have highlighted the role of NETs in the development of intestinal injuries during sepsis (129), and heightened NETosis may lead to dysfunction in intestinal microcirculation (130)