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Safety Profile The safety data from clinical trials reveal a characteristic side effect profile: Common Side Effects: Serious Concerns: Blood pressure effects led to discontinuation of intranasal development in 2007 after transient blood pressure increases were observed

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Nat Rev Endocrinol 8:495502 Ferrannini E, Baldi S, Frascerra S, Astiarraga B, Heise T, Bizzotto R et al (2016a) Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes

10.1007/s10557-004-6219-x Summary Keywords pyrroloquinoline quinone, yes-associated protein, lipid peroxidation, ferroptosis, myocardial hypertrophy Citation Zhou J, Yu T, Wu G, Xu P, Wang C, Su Y, Wang L and Lu Q (2022) Pyrroloquinoline quinone modulates YAP-related anti-ferroptotic activity to protect against myocardial hypertrophy