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In another RDP study, 100 patients with mild to moderate osteoarthritis in the knee were supplemented with 150 mg Pycnogenol per day for three months ( decreased their analgesics consumption, while only 8% in the placebo group reduced the dosage

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While no widespread anaphylactic reactions were reported in clinical trials, there has been an isolated case of a severe local hypersensitivity reaction characterized by intense redness, swelling, and urticaria (hives) at injection sites in a patient who developed anti-sermorelin antibodies

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