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MRS studies of glutamate and glutamine concentrations in schizophrenia have been inconsistent, with some studies reporting an increase, others reporting a decrease or no abnormality ([29,30,31,32,33,34,35], for reviews see [36, 37])

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While the danger remains minimal, recognizing the studys conclusions is critical for both patients and physicians

At doses higher than this, theres unlikely to be additional benefits for muscle mass for most

The key question will be long-term durability, safety, tolerability, and how these therapies perform in broader real-world populations beyond controlled trials