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Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor itself the target of every compound in this class), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (linked to glucose homeostasis and GLP-1 secretion) describe the metabolic terrain a clinician is prescribing into

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Both are injected once weekly using pre-filled pens, come in escalating dose strengths (2.5 mg to 15 mg), and are manufactured under FDA Current Good Manufacturing Practice (CGMP) standards

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