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nevertheless, an open uncontrolled clinical trial in 17,473 postmenopausal women who participated in a one-year dietary intervention that involved decreasing fat intake and increasing intake of fruits, vegetables, and whole grains found those who lost at least 10% of their baseline body weight were more likely to experience a reduction in their menopausal symptoms than those who did not lose weight

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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.James L.P., Simpson P.M., Farrar H.C

The result is sustained, systemic IGF-1 receptor activation that bypasses the regulatory mechanisms controlling endogenous IGF-1 bioavailability

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