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Such additional interaction, facilitated by the disulfide bridge, may altered the enzyme conformation, effecting its catalytic efficiency

A means no, Myo refers to muscle, and Trophic means nourishment: No muscle nourishment. When a muscle has no nourishment, the muscle atrophies or wastes away

They bind to specific receptors on cells and trigger cascades that affect hormones, growth, inflammation, metabolism, or nerve signaling

Patients with GATM deficiencies have milder clinical manifestations which are generally limited to moderate intellectual disability and language disorder