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This central action leads to a powerful reduction in appetite, decreased food cravings, and an enhanced feeling of fullness (satiety), which are primary drivers of the reduced caloric intake and subsequent weight loss observed in clinical trials

Cayres LCF, de Salis LVV, Rodrigues GSP, et al

For instance, Rrm2 is high upregulated in DM CR response

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PubMed Watson JM, Jenkins EJ, Hamilton P, et al