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Analysis suggested GHK Cu upregulates genes associated with tissue repair, collagen production, and anti-aging biology, while downregulating genes associated with inflammation, cancer progression, and oxidative stress (Pickart and Margolina, Biomedicines, 2018)

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These bioactives, when loaded into nanocarriers like SLNs and NLCs, exhibit enhanced dermal penetration, stability, and controlled release profiles compared to crude extracts, making them more comparable mechanistically to synthetic small-molecule inhibitors

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