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Overly dilute solutions are prone to degradation, and overly concentrated solutions may lead to precipitation

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LUXendin-645 imaging To assess access of GLP-1R antagonists to the olfactory bulb from the circulation, awake PPG-YFP mice ( n = 3) were injected subcutaneously with 30 nmol/kg LUXendin645 at a dose volume of 1 ml/kg

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Because it degrades in blood in a pathway involving amino-peptidases, it may not be suitable for people who take medications that inhibit or are metabolized by peptidases (e.g., captopril, a treatment for hypertension).4 Also, based on what we know about other therapeutic peptides, we would say DSIP is contraindicated for women who are pregnant or breastfeeding as well as people with a personal history of cancer