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doi: 10.1016/j.resmic.2018.09.002 42 CorrieLAwasthiAKaurJVishwasSGulatiMKaurIPet al

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AD-cBOs had significantly lower levels of cytochrome c (CYCS, p = 0.033) and ferritin heavy chain (FTH1, p = 0.018) and significantly higher expression of poly(rC) binding protein 1 (PCB1, p = 0.038) and microtubule-associated protein 1 light chain 3 alpha protein (MAP1LC3A, p = 0.042) compared to isogenic brain organoids (Fig

These results suggest that the upregulation of tribbles homolog 3 protein (TRB3) due to diabetes results in impaired cardiac glucose metabolism via the inhibition of cardiac Akt2 function