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Intranasal administration of the optimized formulation exhibited 5.5 times greater relative bioavailability than oral administration of the drug solution, which was attributed to the avoidance of the first-pass effect and enhanced drug permeation across the nasal mucosa

Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD et al (1994) Motor neuron degeneration in mice that express a human Cu Zn superoxide dismutase mutation

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