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Higher-than-normal levels of zonulin suggest increased intestinal permeability, allowing toxins, bacteria, and undigested food particles to leak into the bloodstream

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This gastric stability fed the hypothesis of oral bioavailability, a hypothesis nevertheless difficult to rigorously validate because animal studies predominantly use intraperitoneal or subcutaneous routes

Ethics declarations Competing interests LNY has been on advisory boards or received honoraria or research grants from Allergan, Otsuka, DSP, Sanofi, Alkermes, Abbvie, GSK, Merck, Intracellular Therapies, Servier and Seuiris over the last 3 years