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doi: 162

The study was a randomized, double-blinded, placebo-controlled, crossover trial---the gold standard for scientific trials

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However, a small fraction of APAP undergoes oxidative metabolism by cytochrome P450 enzymes, predominantly cytochrome P450 2E1 (CYP2E1), to form N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive and toxic intermediate