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Brain uptake and efflux of choline moieties Among the metabolite moieties readily measured by 1H-MRS in clinical studies, only the choline moiety is minimally synthesized within the brain and thus dependent on uptake from the systemic circulation [70]

Formulation Considerations for Proteins Susceptible to Asparagine Deamidation and Aspartate Isomerization

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Consequently, simulations suggest that while doxorubicin redox metabolism impacts GSH metabolism, the concentrations required to illicit a toxic response, with either a single or extended exposure, reside outside that of the therapeutic dosing range