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6.2.2 Phase II clinical trials Based on positive Phase I results, researchers initiated the Phase II clinical trial named Airleaf (NCT05238675) in March 2022 ( Besides the Airleaf study, the research team also initiated two additional Phase II clinical trials, Clairafly (NCT05865886) and Clairleaf (NCT05846230) ( The Clairafly trial focuses on evaluating BI 1291583s safety, tolerability, pharmacodynamics, and pharmacokinetics in adult patients with cystic fibrosis-related bronchiectasis ( The Clairleaf study represents a long-term safety and efficacy evaluation study specifically designed for bronchiectasis patients who previously participated in Airleaf or Clairafly trials ( 6.2.3 Future development plans Additionally, the Phase III randomized, double-blind, placebo-controlled clinical trial named AIRTIVITY (NCT06872892) is planned to commence in June 2025 ( 6.3 HSK31858 clinical studies 6.3.1 Study design and population HSK31858 has completed Phase II clinical studies (SAVE-BE) in Chinese bronchiectasis patients ( 6.3.2 Primary efficacy results Study results showed that both doses of HSK31858 could improve clinical outcomes in bronchiectasis patients: Compared to placebo, both the 20 mg group (hazard ratio = 0.52, 95% confidence interval: 0.340.80

what does l carnitine do for you L-Carnitine 250 mg L Carnitine Explained: What This

identified mitochondrial dysfunction as a significant mechanism behind efavirenz-induced liver injury

what does l carnitine do for you L-Carnitine 250 mg L Carnitine Explained: What This

Final Words Glutathione IV therapy offers numerous benefits for detoxification, skin health, immune support, chronic illness management, and athletic performance

what does l carnitine do for you L-Carnitine 250 mg L Carnitine Explained: What This

This dual-target strategy has the potential to overcome the limitations of single-mechanism therapies and improve therapeutic efficacy in severe asthma

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Minutes-long half-lives, once-daily studied dosing, and banned in sport

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