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222-224 In addition, assisted reproductive technique-conceived babies have been found to be more likely to experience perinatal problems (eg, low birth weight and preterm birth) compared with those conceived naturally, and some evidence suggests they may potentially be at higher risk of cardiovascular problems later in life

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Insulin signaling also results in the activation of various phosphodiesterase (PDE) isoforms leading to PDE-catalyzed hydrolysis of cAMP which in turn results in reduced activation of PKA

Higher doses are also concerning for people with rheumatic heart disease, and people undergoing digitalis or anticoagulant therapy due to vitamin E enhancing the anticoagulant effects of these medicines