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At this point, it is clear that the beneficial effects of GLP-1RA on cardiovascular risk factors and physiology outweigh a potential risk of the associated heart rate increase

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In DR, GLP-1RAs vascular stabilization effects (via RhoA/ROCK inhibition) (Wei et al., 2022) could complement anti-VEGF therapy, yet their interaction in modulating angiogenesis remains unexplored

It mediates important physiological effects of the endogenous peptide, GLP-1, in regulating insulin secretion, carbohydrate metabolism and appetite, and thus is well established as a long term clinical target for treating type II diabetes and obesity (Graaf et al