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For decades, tobacco-related disparities have persisted by race and ethnicity, levels of income and education, mental health conditions, sexual orientation and gender identity, and geography

Based on the Logics product applications, the agency concluded that the likely benefit for adult smokers who cease or significantly reduce their cigarette consumption outweighs the risk to youth, provided that the company follows postmarketing requirements to reduce youth access and youth exposure to their marketing

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The proportion of effect mediated was calculated as [-4.27-(-2.62)]/-4.27 for physical health and [-3.34-(-2.11)]/-3.34 for mental health