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When ferroptosis occurs, how does the downregulated GSH/GPX4 regulate the inflammatory process

The antioxidants alpha-lipoic acid and N -acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

As mentioned earlier, if we are not taking good care of ourselves glutathione (GSH) levels can be deficient, and with this comes consequences

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(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans