[21] demonstrated the potential benefits of NAC in limiting this pathophysiological mechanism of liver injury, by inhibiting ROS-mediated endoplasmic reticulum stress, and, thus, showed that it may have significant theoretical effects in inhibiting the ROS-mediated apoptosis pathway [22]
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We quantified mildronate using its deuterated analog ([ 2 H]-mildronate) as an internal standard, while endogenous L-carnitine was relatively quantified using a surrogate matrix
Observations indicate that PD is more prevalent among individuals of Caucasian descent, potentially attributable to a shared genetic predisposition (Tanner and Goldman 1996)