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Preclinical studies demonstrate that tirzepatide promotes healthy adipose tissue expansion (hyperplasia rather than hypertrophy), increases adiponectin secretion, and enhances lipid uptake into adipocytes effectively improving the "metabolic sink" function of fat tissue

Cost and availability are often the deciding factors in the real world, regardless of which drug shows the larger average effect in trials

Chronic Oral Ingestion of L-Carnitine and Carbohydrate Increases Muscle Carnitine Content and Alters Muscle Fuel Metabolism during Exercise in Humans