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Supplementation studies indicate that Se can improve TSH levels in Se-deficient individuals with subclinical hypothyroidism

Concurrently, ER stress can upregulate TH expression, leading to overactivation of dopaminergic neurons and the generation of neurotoxic metabolites, thereby exacerbating apoptosis (1417)

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After removing the magnetic beads, samples were spun down at 20,000 g for 10 min to remove the remaining beads, and the supernatant was transferred to a scintillation vial with 5 mL of Insta-Gel Plus scintillation cocktail (Perkin Elmer #601339)