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The cells were then washed three times with PBS, drained and mounted

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These results show that FOXO4-DRI caused nuclear exclusion of Ser15-phospho-p53 and induced apoptosis in senescent TM3 Leydig cells, and that it acted selectively against senescent cells

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Bone loss during the fat loss period (fat loss model in obese rats) Experimental Design: Animals: Obese SD rats induced by high-fat diet were randomly divided into an obesity control group, a simple weight loss group (30% calorie restriction), and a weight loss+AOD 9604 group (500 g/kg/day)