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Overall, the results suggest that RRM2 acts as a pro-oncogenic molecule and may promote the progression of PTC by activating the PI3K/Akt signaling pathway, regulating key proteins of the cell cycle, and inducing the EMT process, which is in high agreement with previous findings in other malignant tumors

However, very little is known about the mechanism behind the anti-drinking effects of Y1R agonists and Y2R antagonists

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