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In a randomized, double-blind, placebo-controlled trial, tesamorelin reduced liver fat and was associated with less fibrosis progression, and a targeted proteomic and transcriptomic analysis of that trial showed the drug lowered fibro-inflammatory mediators including VEGFA, TGF-1, and CSF1

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Addressing behavioral and psychological aspects of weight loss is also essential for long-term success

Weight loss can help lower blood pressure and cholesterol, and research shows they can protect the heart and kidneys in certain people at higher risk

Dr Brendan Gabriel, a nutrition and health expert at the University of Aberdeen, said the treatment might not be suitable for everyone on GLP-1 drugs, but might help some who are losing muscle mass particularly fast