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Liddle, L

found miR-29b as the only miRNA whose expression was increased in five different in vivo murine muscle atrophy models (denervation, Dex-treatment, fasting, cancer cachexia, and aging) as well as three in vitro atrophy-inducing cell culture models (C2C12 myotubes treated with dexamethasone, TNF-, and H 2 O 2 ) [138]

Results obtained from preclinical studies cannot be directly applied to humans

The following sequences of the target siRNAs and shRNA were designed by GenePharma (Shanghai, China): SLC25A39 siRNAs (5-GGUUACCUCUCUCUUCAUGTT-3), and negative control (si-NC, 5-UUCUUCGAACGUGUCACGUTT-3)

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