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Decreased hepatic TAC, increased hepatic MDA, and histological alterations in hepatic tissue further supported these findings in the current study

The development of less lipophilic drugs with reduced CYP metabolism heightens the potential for metabolism through phase II metabolic routes and consequently involvement of transporters

"Amylin receptor agonism for obesity treatment: Clinical development of cagrilintide." Diabetes, Obesity and Metabolism , 25(4), 891-903

liver, adrenal cortex or lactating mammary glands, the NADPH is used in redox reactions required for biosynthesis of cholesterol, bile salts, steroid hormones and triglycerides