Inhibition of the pathway results in sparse hair or absence of follicles in mice [28,29,30]
A study found that by examining the postmortem brain tissue of suicidal patients with depression, the astrocyte-specific methylation map in the genome showed that glutamate receptor ionotropic kainate 2 and brain-rich guanosine kinase-related protein, which are associated with depressive psychopathology, were less methylated 134
No significant treatment group differences were detected in the cognitive scores at end of study, although numerically greater improvement or less decline on measures of visuospatial functions was demonstrated with testosterone treatment compared with placebo
PMID:16822960 Imbimbo BP, Mant T, Edwards M, et al
The challenge with many interventions is that they lack selectivity, affecting multiple physiological systems simultaneously and creating side effects that limit their practical application or raise safety concerns