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The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1 G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1

4.3 Autophagy Autophagy is an evolutionarily conserved pathway essential for maintaining cellular homeostasis

Moreover, when PQQ exposure is initiated prior to pregnancy, the mice most deprived of PQQ have fewer litters [61]

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The claim was also met with criticism and skepticism from other longevity researchers