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No safety issues were identified in the CRL, nor did the FDA request any additional studies be conducted, according to Endpoints News

Peroxisome Proliferator-Activated Receptor-Gamma Gene Expression in Orbital Adipose/Connective Tissues is Increased During the Active Stage of Graves' Ophthalmopathy

However, they may have some side effects

Skip this combo if you have kidney disease, ulcers, a GI bleeding history, or youre pregnant in the third trimester

By slowing gastric emptying and enhancing the bodys satiety response, these medications may help decrease cravings and improve portion control, making medically supervised weight loss more achievable for appropriate candidates