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P300-mediated histone lactylation has been observed to be predominantly localized at transcription start sites, significantly driving the malignancy of the U87MG GBM cell line and promoting immunosuppression in the GBM microenvironment

The lysate was carefully mixed for 10 minutes at 4 C and then centrifuged at 16,000 RCF for 30 minutes at 4 C

Reduced folate/ThDP exchanger SLC19A1, demonstrating decreased transcript levels 1 month after the bypass, shares the cluster (3 g) with mitochondrial ThDP transporter SLC25A19, ThTPase and BCKDHA (Figure 5A)

Local injection offers no proven advantage and increases complication risk

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