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Novo Nordisk is planning a higher-dose version (CagriSema 2.4/7.2 mg, pairing standard cagrilintide with Wegovy HD-level semaglutide) in a new Phase 3 trial starting H2 2026

Buie T, Campbell DB, Fuchs GJ 3rd, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H

The rationale is straightforward: these peptides work through complementary mechanisms, and together they may address more aspects of disc healing than either can alone