Five miRNAs were enriched in liver: hsa-miR-122-5p, hsa-miR-192-5p, hsa-miR-483-5p, hsa-miR-194-5p and hsa-miR-210-3p, whereas other enriched tissue-specific miRNA were as follows: muscle-enriched miRNAs hsa-miR-193 b-5p, hsa-miR-378c and hsa-miR-378a-3p, frontal orbital gyrus-enriched miRNAs miR-125b-3p and hsa-miR-125b-5p, and pancreas-enriched miRNAs hsa-miR-148a-3p and hsa-miR-130b-3p
This most intriguing and favourable behaviour was observed for the SOD enzymatic system, which is responsible for the conversion of the superoxide anion to oxygen and hydrogen peroxide
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Cheng J, Zhu Y, Dai Y, Li L, Zhang M, Jin D, Liu M, Yu J, Yu W, Su D
34,40,41 Ferroptosis, another form of regulated cell death characterized by iron-dependent accumulation of ROS, lipid peroxidation, and oxidative membrane damage, is increasingly recognized as a key contributor to APAP-induced liver injury
