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Folate is needed for amino acid and nucleic acid (DNA and RNA) metabolism

It is used to make a potent vasodilator called nitric oxide

Radiation-induced hypopituitarism is dose-dependent

Second, in humans with loss-of-function variants in SLC22A1, which decrease the uptake of metformin into the liver, the ability of metformin to lower A1c levels is not impaired (48)