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[8] The European Union and Japan also reviewed safety and concluded as had the United States that there was insufficient evidence to set an upper limit for vitamin K

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In a three-month study with 58 hypertensive patients, taking the anti-hypertensive drug nifedipine (a calcium channel blocker), the plasma levels of vasoconstrictor molecule endothelin-1 were significantly lowered by 9% after one month and by 16% after three months in the group taking 100 mg Pycnogenol compared to the placebo group ( compared to the placebo group