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The primary objective of this substudy was to assess mean relative change from baseline in liver fat (LF) at 24 weeks in participants from that study with metabolic dysfunction-associated steatotic liver disease and 10% of LF

The slightly slower and steadier absorption from abdominal fat can soften the drug's initial peak concentration, which is often when nausea hits hardest

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Lifestyle Support Between Medication Adjustments Even while taking semaglutide, building sustainable habits in nutrition, movement, and sleep strengthens your results and may reduce the weight rebound risk if you ever do stop therapy

doi:10.1056/nejmoa1411892 5