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Furthermore, IS activates NF-B signaling, increasing pro-inflammatory factors such as cyclooxygenase-2, ROS, TNF-, IL-6, and IL-1, while suppressing antioxidant factors such as heme oxygenase-1 and superoxide dismutase 2, through Nrf2 pathway inhibition, thereby disrupting intestinal homeostasis and promoting systemic inflammation in mice ( Figure 3 ) [116]

De Nijs M, Mengelers MJB, Boon PE et al (2016) Strategies for estimating human exposure to mycotoxins via food

253255 OxLDL interacts with various receptors, such as lectin-like oxidized LDL receptor-1 (LOX-1), TLR4, and RAGE, activating inflammatory pathways and increasing ROS accumulation

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& Yuste, R